Long-Term Inhalation Reproductive and Teratogenic Toxicity Evaluation of Nitrous Oxide Plus Halothane

摘要

The report discusses the long term effects of exposure to nitrous oxide plus halothane on the reproductive performance of female rats and the development processes in their offspring. Exposure of mated female rats to the combinations of nitrous oxide and halothane results in reduced ovulation and implantation efficiency at the higher level of exposure during the first six days after mating and a slightly retarded development of the fetuses at both levels of exposure. Exposure to 10 parts per million (ppm) of halothane plus 500 ppm of nitrous oxide can cause toxic effects on reproduction in rats, which should be of concern to humans.