Influenza Studies: Vaccine Trials, Anti-Influenza Compounds Trials, Virologic Surveillance and Clinical Surveillance

摘要

Studies of clinical and serologic responses following immunization with whole virus and split product monovalent (A/USSR/77) and trivalent (A/USSR/77-A/Texas/77-B/Hong Kong/72) influenza vaccines in children, adolescents and adults are reported. Implementation of one phase of the vaccine trials (children 6 mos. of age through 3 years of age) was delayed because of the unavailability of vaccine. Intake in this study is still in progress. Clinical surveillance during the study period revealed no unusual illnesses in previous recipients of A/NJ/76 influenza vaccines. Subtle side effects were noted in association with amantadine prophylaxis in young adults. During the study period, 651 influenza surveillance cultures were processed and 27 influenza A strains and seven influenza B strains were recovered.