Tier II Mutagenic Screening of 13 NIOSH Priority Compounds: Individual Compound Report; Styrene Oxide

摘要

Styrene-oxide (96093) (SO) was subjected to a tier II mutagenic test screening program. The screening included the following assays: unscheduled DNA synthesis (UDS) assay in human diploid fibroblasts with exposures of 3 hours duration and concentrations up to 50 micrograms per milliliter of culture medium; dominant lethal test in male rats with exposure to atmospheres containing 15 or 100 parts per million (ppm) SO styrene-oxide for 7 hours per day for 5 consecutive days; sperm abnormality test in male mice using the same conditions; cytogenetic test in male and female rat bone marrow cells using the same exposure conditions or a single exposure of 7 hours duration; and sex linked recessive lethal test in Drosophila-melanogaster with exposure of 100ppm for 150 minutes.