Intravenous Lethality and Toxicity Studies in CDF1 Mice and Toxicity Study in Beagle Dogs of Henkel's Compound (NSC-296,934) (Phase II Report of Task 1)

摘要

Henkel's compound (NSC-296,934) was given intravenously to mice and dogs for the evaluation of lethality and toxicity. There was no apparent sex difference in the lethality doses in mice. In mice, the combined sex LD(10), LD(50), and LD(90) were 120.7, 148.7, and 183.2 mg/kg (362.1, 446.1, and 549.6 mg/sq m in the single dose lethality study and 53.24, 61.55, and 71.15 mg/kg/day (159.72, 184.65, and 213.45 mg/sq m/day) in the five daily dose lethality study. In the toxicity studies of both species, clinical signs, hematology changes (also serum biochemistry changes in dogs), and pathologic lesions were closely related and dose related. Reversibility was evident in surviving animals. Males and females were similarly affected.