Exploratory Research on Mutagenic Activity of Coal-Related Materials. Progress Report, January 1-June 1, 1982

摘要

Mutagenicity assays of materials from the EPA/DOE Fossil Fuels Research Repository have been extended to the following: vacuum bottoms from syncrude and fuel oil modes; H-coal distillate (raw); and HDT H-coal distillates, low medium and high severity. Assays were also completed for organic solvent fractions from these and previously prepared materials: coal oil A, shale oil A, petroleum crude A, syncrude and uncentrifuged product synthoil. All whole materials were mutagenic in the presence of S9. Vacuum bottom samples 1311 and 1315 proved to be similar to vacuum bottoms ETTM-11 and ETTM-18 supplied to us on previous DOE contracts. Similarities were noted in the magnitude of TA98 response to the whole sample, in their distribution into solvents of differing polarity and in the mutagenicity of organic solvent fractions. Our mutagenicity data from assays of unfractionated samples continues to be in good agreement with published data from another laboratory. (ERA citation 07:052645)