Application of Short-Term Biotests to Health Risk Analysis of Fluorinated Compounds

摘要

The use of various fluorinated compounds as insulating media for electric power transmission facilities is an example of a developing technology which may affect human health. Data on cytotoxicity, generated when the species, Saccharomyces cerevisiae, was exposed to perfluoro-2-butyne (PFB), sulfur hexafluoride (SF sub 6 ), sulfur dioxide (SO sub 2 ), octafluorocyclobutane (c-C sub 4 F sub 8 ), and hexafluorocyclobutene (c-C sub 4 F sub 6 ) are discussed. How such data when combined with biological data on well characterized toxic agents, can serve as input to an estimate of the human health impact or acceptable exposure limits for these fluorinated compounds is described.