Support: Letter from (Confidential) to USEPA Reporting re: Acute Oral Toxicity Study in Rats with a Mixture Containing Cymoxanil and a Substituted Heterocycle, dated 09/16/1999. (Sanitized)

摘要

The R&D mixture contained cymoxanil and substituted heterocycle. Death occurred in 0/5, 2/5, and 4/5 male rats dosed at 1000, 2000, and 3000 mg/kg, respectively. Death occurred in 1/5, 2/5, and 5/5 female rats dosed at 500, 1000, and 3000 mg/kg, respectively. Abnormal gait or mobility was observed in surviving female rats in the 500 mg/kg dose group. Lethargy was observed in surviving female rats in the 500 and 1000 mg/kg dose groups. The oral LDso was 2148 mg/kg for male rats and 1025 mg/kg for female rats.