Initial Submission: Letter from (Confidential Source) to USEPA Reporting Results in Acute Dermal Toxicity Test of 2,6-Dichloroaniline in Rats, dated 08/06/1999. (Sanitized)

摘要

Five male and female Fischer 344 rats were given either a single dermal application to provide a dose level of 2000, 2500 or 5000 mg/kg or a subcutaneous injection to provide a dose level of 2000 or 2500 mg/kg of the study compound dissolved in DMSO. Clinical observations indicate that at 5000 mg/kg dermal application whole body twitching was observed in the one surviving female rat and three of the five male rats were laterally recumbent with whol body twitching a the above dermal level.