A Twenty Four Month Toxicology Study in Fisher-344 Rats Given Terephthalalic Acid (18-month Interim Status Report).

摘要

Bis(2-ethylhexyl) terephthalate was evaluated for combined chronic toxicity and carcinogenicity. The test substance was administered in the diets of male and female Fischer-344 inbred rats at concentrations of 20, 142, and 1000 mg/kg/day. Clinical evaluations revealed no treatment-related signs, however, eye opacities (cataracts) occurred frequently in all groups. At 1000 mg/kg/day, body weights and female liver weights were reduced. There were no consistent reductions in food consumption. There were no treatment-related effects evident from the gross and histopathologic examinations conducted at 6 and 12 months. At 18 months, twobasic lesions of the females in the 1000 mg/kg/day level appear to be associated with treatment. These were hyperplasia and/or transitional cell adenomas of the urinary bladder and adenomas or adenocarcinomas of the uterus.