CHARACTERISTICS OF AMINO ACID ACCUMULATION BY ISOLATED INTESTINAL EPITHELIAL CELLS

摘要

Accumulation of neutral amino acids by isolated chick epithelial cells has been studied and the results discussed in terms of the iongradient model and a model invoking a direct input of energy. The cells establish 4-8 fold concentration:gradients of amino acids. The accumula-tion is sodium-dependent, inhibited by high extracellular potassium levels, and sensitive, to a variety of metabolic inhibitors. Also, amino acid uptake is depressed by actively transported sugars and certain other amino acids, and is stimulated by phloridzin.