Chronic Dermal Toxicity of Epoxy Resins. I. Skin Carcinogenic Potency and General Toxicity

摘要

This report quantifies the cutaneous and systemic response of male and female C3H mice to skin application of selected commercial epoxy resins and amine curing agents, at the maximum tolerated dermal dose (MTDD). Resins tested were: diglycidyl ether of bisphenol A (DGEBA) (CAS no. 1675-54-3); mixtures of the same resins with bis(2,3-epoxycyclopentyl) ether (CAS no. 2386-90-5; diglycidyl ether of resorcinol (CAS no. 101-90-6); N,N'-diglycidyl-5,5-dimethylhydantoin (CAS no. 15336-81-9); diglycidyl ether of neopentyl glycol (CAS no. 17557-23-2); A 70:30 mixture of the hydantoin and neopentyl glycol base resins; the amine curing agent menthane diamine (CAS no. 80-52-4); and a dutectic mixture of meta-phenylenediamine (CAS no. 108-45-2) and DGEBA. A DGEBA manufactured by Union Carbide Corporation (Material E, Appendix A) in the mid-1970's and assayed for skin carcinogenicity previously was chemically characterized. The results of this analysis are included with the present data for comparison purposes. Background information on the special statistical methods used is presented in Appendix C. (ERA citation 06:024384)