Preparation of Zirconium Molybdate Gel for (99M)Tc Gel Generator

摘要

Zirconium molybdate gel has excellent characteristics for use as column matrix material of /sup 99m/Tc generators. In this work, zirconium molybdate gels were prepared under different conditions; pH's of molybdate solutions from 2.5 to 7.0, Mo:Zr molar ratios from 0.7:1.0 to 1.3:1.0, drying temperatures from an ambient temperature to 200 deg C, and drying times from 1 h to 25 h. Contents of water, nitrate, molybdenum and zirconium were measured to examine the fundamental conditions in gel preparation. The Mo:Zr molar ratio was 1.0:1.0 for the most of gels obtained. A /sup 99m/Tc generator was prepared with an amorphous zirconium molybdate containing a tracer level of /sup 99/Mo as column matrix material. Elution of /sup 99m/Tc was rapid and the average elution efficiency was 90 % for 6 ml elutions. Contents of radionuclidic impurities, Zr and Mo in the eluates, were low enough to meet the pharmacopoeia requirements for human use. (ERA citation 14:013274)