Determination of the Feasibility of Preparing Vancomycin Microparticles.

摘要

The main objective of this project was to develop, prepare, and deliver 25 g of vancomycin microcapsules, 25 g of placebo microspheres, and 5 g of vancomycin, USP to USAIDR. In vitro release studies, in addition to antibiotic microbial assay, demonstrated that the BIOTEK vancomycin microcapsules met all the criteria stipulated in the contract. The microcapsules maintained a sustained release of therapeutic levels of vancomycin and inhibited bacterial growth of Staphylococcus aureus for 19 days. The preparation of these vancomycin microcapsules required no methylene chloride and the release of vancomycin from the microcapsules was not adversely affected by sterilization with gamma irradiation.