Evaluation of the Vesicating Properties of Neutralized Chemical AgentIdentification Set (CAIS) Components

摘要

Vesication and skin irritation studies were conducted in hairless guinea pigs toascertain the vesicant and skin irritation potential of chemically-neutralized Chemical Agent Identification Sets (CAIS). CAIS are training items that contain agent (HD, HN, or L) and were declared obsolete in 1971. Animals were dosed with 'test article' EITHER NEAT HD, 10% agent/chloroform solutions or product solutions (wastestreams) and evaluated for skin-damaging effects (gross and light microscopic). Product solutions from the chemical neutralization of CAIS (either agent/chloroform or agent/charcoal) produced no microblisters. Dermal application of product solutions from the neutralization of neat HD resulted in microvesicle formation (vesication). All agent-dosed (either agent/chloroform solutions or HD) sites exhibited micro-blisters as well as other histopathologic lesions.