Prostate Specific Antigen Density of the Transition Zone in Ethnically Diverse Men

摘要

There are significant racial differences in unscreened populations in both prostate cancer incidence and mortality rates. However, to date there are no widely available prostate cancer strategies that can be applied to ethnically diverse men. Some have suggested that this is due to inherent biological differences in prostate cancer growth between African American and Caucasian American males. This concept is supported by increased levels of serum prostate specific antigen in African American males versus Caucasian American males. We have reported that the portion of the prostate that is more commonly associated with benign prostate hyperplasia, the transition zone, is more prominent in African American versus Caucasian American males. Given that this area, the transition zone, produces PSA, it is very conceivable that differences in PSA may reflect a different incidence of benign prostate growth in African American versus Caucasian American than to differences in prostate cancer. This training grant helped support the concept development by the PI, Alexis E. Te, of a study to determine if a new prostate cancer detection strategy, PSAT (the ratio of serum PSA to the volume of transition zone of the prostate) is different among African American males, Caucasian American males and males of other ethnicity's.