Hydrophobicity Based Neural Network Method for Predicting Transmembrane Segments in Protein Sequences.

摘要

Transmembrane proteins play vital roles in living cells. The difficulties in determining the topology of transmembrane protein experimentally and the increasing amino acid sequence data from genome projects provide great demand for computational methods to predict the region of transmembrane segments in protein sequences. A hydrophobicity based supervised learning vector quantization neural network prediction method is presented. The prediction accuracy is above 90% and comparable to existing methods.