Clinical Trial of Exercise on Circadian Clock Resetting

摘要

Specific Aim 1: test the hypothesis that a 9-hr phase delay shift of the duty-rest schedule, such as that required for either transmeridian travel or night operations, will induce physiologic maladaptation in the endogenous circadian rhythms of core body temperature, plasma melatonin, reaction time, alertness and performance; Specific Aim 2: test the hypothesis that multiple nightly bouts of exercise will induce significant delays in the endogenous circadian rhythms of core body temperature, plasma melatonin, reaction time, alertness and performance relative to the control group, even in- the absence of properly timed exposure to photic cues; Specific Aim 3: test the hypothesis that exercise-induced phase delay shifts of will facilitate adaptation of these rhythms to an imposed duty-rest schedule, thereby improving sleep efficiency during daytime sleep and improve reaction time, alertness and performance during scheduled waketime at night relative to control group.