Racial Differences in Prostate Cancer: Influences of Health Care Interaction and Host and Tumor Biology.

摘要

The purpose of the Development Award Proposal was to form a Consortium of nine institutions to conduct a comprehensive study of men with newly diagnosed prostate cancer (Cap) that exhibit different CaP mortality rates-500 North Carolina African Americans (high risk), 500 Louisiana African Americans (intermediate risk) and 1000 Caucasian Americans in both states (low risk). The scope of the proposed studies is to categorize the relative contributions to CaP mortality from racial differences in: (1) interaction with the health care system; (2) biology of the host; and (3) characteristics of the tumor. The Development Award allowed us to submit a Consortium proposal that was approved for funding; assemble a team of investigators, administrative structure and scientific and lay oversight committees to facilitate the proposed studies; pilot our methods in a small study that demonstrated that men of both races in both states would participate in the proposed studies; verify that research specimens were suitable for the analyses proposed; improve the method for measurement of apoptosis in CaP; demonstrate diagnostic prostate biopsies could be microarrayed; assemble the interview instruments; formulate a plan to meet the new HIPA requirements; and begin the development of the central Consortium database.