Malaria Vaccines for Travelers

摘要

An effective malaria vaccine would eliminate most of the obstacles to malaria prevention, excepting only the pre-travel visit(s) to receive the vaccine from a health care professional. As with vaccines against other infectious diseases, overall benefits for the traveler and for public health would be immense. Even if purchase costs were similar to those of chemoprophylaxis, vaccination would represent a one-time expense with the enviable property 'fire and forget,' meaning that once administered, no further thought or action would be required for malaria prevention during the period of protection afforded by the vaccine. Even if efficacy as measured in controlled trials lagged behind that of drug prophylaxis, the real world effectiveness would likely be superior due to automatic compliance following vaccine administration. Travelers would be saved the inconveniences of carrying drugs, tolerating side effects, and continuing administration after travel has ended.