Molecular Markers of Estrogen Metabolism and Progression From High- Grade Prostatic Intraepithelial Neoplasia (HGPIN) to Prostate Cancer

摘要

The purpose of this case-control study is to investigate the association between genetic and encocrine markers of estrogen metabolism and prostate cancer progression. Androgens (e.g., testosterone) may be critical in prostate cancercinogenesis, but there is accumulating evidence that estrogens facilitate progress during the later stages of prostate cancer formation 1-4. To explore the role of estrogens in human prostate carcinogenesis, we proposed to investigate the association between genetic and endocrine markers of estrogen metabolism and the detection of high-grade prostatic intraepithelial neoplasia (HGPIN) and stage I/II/III prostate cancer. The first project year included protocol development and IRB approval, and the second year focused on subject recruitment and data collection. The third year focused on recruitment, data collection, and analysis. Specific accomplishments include recruitment of 717 subjects to the protocol (95% of eligibles). We have conducted several analyses looking at the association between genetic variants or obesity and HGPIN or prostate cancer. We have exceeded recruitment goals, and extended interpretation to current public health priority. Further details provided below are in parallel with the statement of work.