Neurotoxins and Neurodegenerative Disorders in Japanese-American Men Living in Hawaii.

摘要

Results from the Honolulu-Asia Aging Study (HAAS) supported by this project showed Parkinson's disease (PD) risk increased with milk consumption, olfactory dysfunction, excessive daytime sleepiness, and low LDL cholesterol. Olfactory dysfunction and constipation were found to be associated with incidental Lewy bodies. A polymorphism of the MDR1 transporter gene was associated with PD. The supplement aim was to measure organochlorine levels in all brains from the HAAS archive and to examine the association of brain organochlorine levels with clinical and pathological endpoints obtained through prior and ongoing research. Frozen occipital blocks from 421 brains were sent to Dr. E.D. Pellizzari of Research Triangle Institute for organochlorine level assays. These are complete. Preliminary analyses demonstrate that measurable A- chlordane, T-nonachlor, or Methoxychlor levels were found significantly more frequently in brains with Lewy bodies (including PD cases) than in those without Lewy bodies.