Development of Convergence Nanoparticles for Multi-Modal Bio-Medical Imaging; Final rept. 1 Feb 2007-1 Feb 2008

摘要

The purpose of this project is to develop a novel, highly versatile, multi-functional convergence nanoparticle system for their advanced biomedical applications. Inorganic nanoparticles are now emerging as a promising candidate to revolutionize current science and technology. By utilizing inorganic nanoparticles, it is possible to have the ability to control physical/chemical properties of materials as we desire, which is not allowed in current technology. Furthermore, these inorganic nanoparticles exhibit improved physical/chemical properties, compared to classical bulk materials. Such enhanced properties of inorganic nanoparticles make them useful as key components for futuristic nanodevice applications although there have been remarkable progresses in the synthesis of inorganic nanoparticles during the past decade, currently developed nanoparticles possess only simple and basic functions and therefore have difficulties to be utilized in advanced applications. To develop multi-functional convergence nanoparticles, we planed three-year research project. As the first stage, in this year, we fabricated prototype convergence nanoparticles and we first studied multi-functionality of magnetic nanoparticle, MR (magnetic resonance) contrast effect and heat generation ability. Based on the magnetic nanoparticle, we synthesized prototyped convergence nanoparticles by conjugating with optical component and radioisotope. Then, we have accomplished feasibility test on the biological system such as Amyloid Beta aggregation and lymph node detection.