Pathophysiological Alterations In The Basolateral Amygdala And Neurodegeneration Of Limbic Structures During Epileptogenesis Induced By Status Epilepticus

摘要

As a model of epileptogenesis and temporal lobe epilepsy (TLE), status epilepticus (SE) triggers structural and functional neuronal changes that take place during a latent period of weeks or months after SE, followed by the development of spontaneous seizures. Neuronal loss and synaptic reorganizations of limbic structures during epileptogenesis in the rat brain are similar to neuropathological observations in TLE patients. The development of regimens that can inhibit epileptogenesis requires understanding the alterations that occur during epileptogenesis in brain regions that are important in epilepsy.