Pulmonary Oxygen Toxicity: The Role of Biogenic Amines, the Sympathetic Nervous System, and Pulmonary and Systemic Hemodynamics.

摘要

This research project was conducted to evaluate the role of systemic factors in the pathogenesis of pulmonary oxygen toxicity. Studies were conducted on conscious adult male mongrel dogs. The following conclusions were reached: (1) Severe systemic hyperoxia has a significant aggravating effect in the pathogenesis of pulmonary oxygen toxicity; (2) Endogenous circulating and pulmonary tissue biogenic amines do not appear to have a direct relationship with the severity of lung damage by oxygen. (3) Surgical denervation of the lung does not protect it from toxic effects of oxygen; and (4) Pathologic changes in the lungs do not appear to be the consequence of hemodynamic changes while animals breathe 100% oxygen at 1 Ata or 2 Ata until they died. (Author)