Metabolism of the Non-Hepatic Splanchnic Area in Baboons and the Effects of Endotoxin

摘要

Values of several parameters of lipid and carbohydrate metabolism were established in the Non-hepatic splanchnic area (NHSA) of anesthetized baboons under normal conditions. The tissues in this area consistently remove free fatty acids (FFA) and glucose. About 20% of palmitic and oleic acids are extracted. Of the amount of palmitic acid taken up, 10% is oxidized. 8% of the total CO produced by the NHSA can be accounted for by FFA oxidation. The metabolic effects of E. coli endotoxin adminstration were studied in terms of alterations in metabolite concentrations systemically and in the NHSA. Arterial FFA levels, as well as the flux of palmitic and oleic acids decreased substantially >60 min. after endotoxin administration. Arterial glucose concentrations decreased at >60 min., lactate concentrations increased significantly, AcAc/beta-OHB ratios decreased significantly, both at 60 min. following toxin injection. Metabolic changes in the NHSA were inconsistent. (Author)