Chemotherapeutic Agents in Ocular Metallosis.

摘要

Although iron and copper foreign bodies enter the eye as metallic fragments, once inside they dissolve and produce an insidious chemical toxicity. Delayed retinal damage may thus cause marked visual loss in an otherwise healthy eye. Since the onset of chemical damage to the eye from iron and copper foreign bodies is always delayed by at least a few days, and often much longer, detoxification of the foreign body during this period appears feasible. Since avoidance of surgery or, at least, a temporary delay to allow proper medical evaluation and transfer to improved treatment facilities would be distinct benefit to the treatment of such ocular injuries in a military setting, information on these chemical agents was sought. Both removal of intraocular metal and prevention of retinal damage were investigated in an animal model.