Determination of Cyanide and Nitroprusside in Blood and Plasma.

摘要

A procedure was refined for quantitative isolation of cyanide by gas transfer from the acidified blood or plasma samples. The cyanide was trapped in dilute alkali and quantified as the pyridine/pyrazolone complex. The within-day coefficient of variation was 2% which increased to about 2.5% for the day-to-day variation. Nitroprusside used as a hypotensive agent in clinical medicine provides a risk of cyanide toxicity when the rate of administration or the total amount of drug was given is excessive.