The Correlation of Animal Response Data with the Yields of Selected Thermal Decomposition Products for Typical Aircraft Interior Materials.

摘要

The purpose of this report is to describe the correlations between animal response data and the yields of selected thermal decomposition products. Seventy-five aircraft interior materials, including panels, fabrics, foams, and thermoplastics were thermally decomposed under conditions of oxidative pyrolysis in a tube furnace. In one experiment performed at the Civil Aeromedical Institute (CAMI), the thermal decomposition products were directed into an animal exposure chamber containing male albino rats. Both times-to-incapacitation (ti) and times-to-death (td) were recorded. In a separate experiment performed at the National Aviation Facilities Experimental Center (NAFEC), the thermal decomposition products (TDP's) were collected and analyzed for CO, HCN, H2S, HCl, HBr, NO2, SO2, HCHO, and HF yields. Multivariate linear regression analysis is used to correlate the times-to-incapacitation with the yields of the nine TDP's. The coefficients of correlation (R) between TDP yields and 1/ti values exceed 0.95 for all usage categories except panels, for which R=0.80. In addition, the coefficients of correlation between observed and predicted 1/ti values for four 'unknown' materials in each of several usage categories are: panels = 0.393, foams = 0.948, fabrics = 0.968, and thermoplastics = 0.988. Times-to incapacitation are related primarily to the yields of systemic toxicants (HCN, CO, etc.) rather than the yields of irritant TDP. In general, HCN is more important for describing 1/ti values than CO, although CO is the predominant toxicant for thermoplastics and coated fabrics. (Author)