Studies on PGB sub x. Isolation of a PGB sub x with reduced Inhibitor Content

摘要

PGBx was separated into two fractions by dialysis against pH 6.5 phosphate buffer. The retentate, which amounted to 90% of the total PGBx, showed in vitro PGBx effects similar to the unfractionated PGBx, i.e., activation at low concentration, inhibition at high concentration. The dialysate fraction showed primarily PGBx activation with only minimal inhibition properties. It is concluded that the activation and inhibition effects of the PGBx complex are caused by different molecular species in the complex. (Author)