Improved Logistics for Chemical and Biologics Decontamination for Deployed Military.

摘要

The primary objective of this contract is to impart CWA neutralization capability into hydrogels with proven efficacy in the physical decontamination of radiological, TICs, TIMs and other contaminants, to achieve efficient decontamination of CWAs that have absorbed into sorptive substrates, via physical removal, neutralization or both. A further objective is to develop strategies to impart bactericidal and sporicidal capability into the systems developed with the ultimate objective being the development of a single CBRN system that will be effective against CWAs and BWAs as well as radiological contaminants, TICs and TIMs. The development of several formulations (both one- component and two-component systems) that demonstrate significant neutralization efficacy against VX, G-agents, and mustard gas simulants in solution and in substrate testing has been achieved. Screening evaluations of a variety of catalyst systems against CWA simulants performed during the initial quarters (Quarters 1 and 2) of this initiative demonstrated that the lanthanide catalyst systems had superior performance as compared to the other catalysts under evaluation. These lanthanide catalyst systems were further modified via adjustment of the type/concentration of lanthanide ion salts and/or the incorporation of a variety of components such as co-solvents, emulsifiers, and other additives to improve their neutralization efficacy on a variety of contaminant/substrate combinations. These modifications have resulted in the development of lanthanide catalyst systems that show enhanced neutralization rates against CWA simulants, approaching a 2-log reduction (99%+ decontamination efficacy) of initial challenge, when used as one-component systems (independent of the hydrogel component) or as two-component systems when combined with the DeconGel hydrogel template (either mixed before use or applied in sequence).