A Neurobehavioral Study of Rats Using a Model Perfluorinated Acid, NDFDA.

摘要

Fischer 344 rats were treated with 10,20, or 30 mg/kg of nonadecafluorodecanoic acid (NDFDA) on day 12 of gestation. Negative controls were given the vehicle (propylene glycol and water; 50:50) and positive controls were given a single ip injection of 500 mg/kg hydroxyurea (diluent, physiological saline). Developmental eruption, eye opening, and growth) and behavior, NDFDA was found to produce increased visuomotor development (visual placing). It is also caused decreased prenatal and postnatal weight gain, delayed cliff avoidance and surface righting, decreased open field rearing, aberrant swimming development and increased auditory startle. The observed effects indicate that NDFDA is a potential toxic neurochemical teratogen. (Author)