Animal-Model Studies of Radiation-Induced Emesis and Its Control

摘要

This paper reviews work conducted on the subject of radiation-induced emesis. Emesis is considered primarily as a facet of the prodromal syndrome which indicates that a person may have received sufficient radiation to provoke performance decrement of some degree. The subjects were adult male dogs. Four radiation sources were used, and doses ranged between 140 and 800 rad. An orderly progression of work led to the identification of three drugs that, given together 30 minutes prior to cobalt-60 irradiation, raised the emetic threshold about 90%. One experiment, however, suggested that these same drugs may have little benefit when neutron irradiation is used.