Dermal Hazard Evaluation of Diethyl Chloroethyl Amine Underwear Fabric Treatment

摘要

To provide guidance for further skin testing, diethyl chloroethyl amine -- treated cotton underwear fabric was applied in patch form to the intact and abraded skin of New Zealand White rabbits. Treated cotton fabrics OD III DS 0.144 and White DS 0.079 did not cause primary skin irritation in rabbits under controlled test conditions. It was recommended that cotton fabrics reacted with diethyl chloroethyl amine to a degree of substitution (DS) of less than 0.145 mole of amine substitute/mole of cellulose monomer unit be approved for further skin testing, including prophetic human patch testing. (Author)