Molecular Recognition, Catalysis, and Transport in Polymerized Surfactant Vesicles

摘要

Exploitation of biological-membrane-inspired chemistries for reactivity control molecular transport and recognition, drug delivery, and artificial photosynthesis has gained considerable importance. Membrane mimetic chemistry, as this area of research has become known, is not concerned with faithful modeling of cell membranes. Essential components of natural systems have been re-created by chemists in membrane mimetics, mostly from man-made molecules. Surfactant bilayer vesicless have been one of the systems utilized. They interact with, transport, and are permeable to substrates. Hydrophobic molecules can be distributed among vesicle bilayers. Alternatively, they can be anchored by a long chain terminating in a polar head group. Polar molecules, particularly those that are electrostatically repelled from the inner surface, move freely in water pools trapped within vesicles. Once large substrates are trapped, they remain within the vesicles for days to weeks. Small ions can either diffuse across the bilayers or be transported through the bilayers with the aid of pores or carriers. Surfactant vesicles lack long-range stabilities and controllable permeabilities. Recognizing the need for these properties led to the synthesis of polymerized vesicles. Attention is focused here on vesicles prepared from styrene-containing surfactants 1-3 and from mixtures of dipalmitoylphosphatidyl choline, DPPC, and 3. Kinetics of vesicle photopolymerization, proton transfers, hydrolyses, and catalyst stabilization in polymerized vesicles will be delighted.