Highly Efficient Asymmetric Reduction of Alpha-Tertiary Alkyl Ketones with Diisopinocampheylchloroborane

摘要

(-)-Diisopinocampheylchloroborane, which reduces many aralkyl and heteroaralkyl ketones with remarkably high stereoselectivity, has now been found to reduce alpha-tertiary alkyl ketones with similar high enantiomeric excess. Such ketones have resisted asymmetric reduction by Alpine-Borane and many other reagents previously described.