Metabolism of Nitroguanidine and Nitrosoguanidine by Rat Hepatic Subcellular Fractions

摘要

The metabolism of nitroguanidine (NG) and nitrosoguanidine (NsG) by rat hepatic subcellular fractions was examined. The microsomal fraction and 10,000 x g supernatant from untreated and phenobarbital - treated animals and the 9,000 x g supernatant from Arochlor-induced rats were used for this study. The in vitro metabolism of substrate was measured by HPLC. The results indicate that neither NG nor NsG are metabolized by the hepatic subcellular fractions.