Trimer of 15-Dehydro-PGB1 Improves Recovery of Mitochondrial Function after Renal Ischemia

摘要

The efficacy of (PGB1)3 in protecting renal mitochondrial function from ischemic reperfusion injury was firmly established in a series of experiments in rats. Renal ischemia was induced by unilaterial closure of the renal artery with an arterial clip. After 48 minutes of ischemia the clip was opened to recover blood flow. At this time treated animals were given a bolus injection, I.P., of 2.5 mg/kg (PGB1)3. Sham controls received an injection of the vehicle. The animals were sacrificed 24 hours later, renal mitochondria were isolated and their function analyzed. The data indicate that a bolus injection of (PGB1) 3 given at the time of reflow provides significant improvement of mitochondrial function after 48 minutes of renal ischemia in the rat.