Neurobiology of Learning and Memory: Modulation and Mechanisms

摘要

It has been known for many years that the retention of newly-acquired information can be modulated by a variety of treatments if the treatments are administered shortly after training. Such findings suggest that the processes underlying memory storage may be modulated by endogenous systems activated by training experiences. Our research has examined the possibility that hormonal systems activated by training may serve this role. Our recent work has focussed on the central mechanisms underlying the effects, on memory modulation, of treatments affecting adrenergic and opiate receptor systems. The findings of our recent research supported by this contract strongly suggest that treatments affecting adrenergic receptor systems as well as opiate receptor systems modulate memory through influence involving noradrenergic receptors in the amygdala. Keywords: Epinephrine, Pharmacological antagonists, Nerve transmission, Nerve cells, Cerebral cortex, Learning, Behavior. (aw)