Discovery and Development of Therapeutic Drugs Against Lethal Human RNA Viruses:A Multidisciplinary Assault

摘要

Continuation of a vigorous investigation sharply focused on the isolation,characterization and structural elucidation of new and potentially useful antiviral drugs from marine animals and plants was pursued. The renewal approval allowed further progress toward the isolation and characterization of novel antiviral substances from confirmed active extracts of marine organisms and both higher and lower plants. The synthetic studies with narciclasine was continued and the supply of pancratistatin from both semi-synthetic and botanical sources was studied further. RNA Viruses; Antiviral Drug Discovery; Pancratistatin and related antiviral leads; RA I; BD; Natural Products