Inhalation Uptake and Metabolism of Iodohalogenated Compounds, CF3I, C6F13I, andC3F7I

摘要

The purpose of this study was to measure the tissue to air partition coefficientsand to describe the uptake and distribution kinetics of iodohalogenated compounds iodotrifluoromethane (CF3I), perfluorohexyl iodide (C6F13I) and l-iodoheptafluoropropane (C3F7l) via closed chamber recirculating gas uptake methods. Inhalation pharmacokinetics for all chemicals were determined experimentally in Fischer-344 (F-344) male rats. A physiologically based pharmacokinetic (PBPK) model was used to describe mathematically the disposition and metabolism of the chemicals employing chemical-specific parameters and apparent whole-body metabolic constants calculated from these expenments.