Using NMR to determine the relative stereochemistry of 7,7-diaryl-8,8 '-dimethylbutan-1-ol lignans

摘要

Due to their linear, freely rotatable, structure many natural 7,7-diaryl-8,8'-dimethylbutan-7'-ol lignans are reported without any stereochemical assignment. Analysis of synthetic 8,8'-dimethylbutanol lignans and analogues reveals significant differences between the NMR data of syn-and anti-isomers. This information was then used to determine the relative stereochemistry of the C-8 and C-8' methyl groups in previously undefined natural products. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.