Biotransformation of cadinane sesquiterpenes by Beauveria bassiana ATCC 7159

摘要

Incubation of cadina-4.10(15)-dien-3-one with Beauveria bassiana ATCC 7159 has resulted in the production of nine novel sesquiterpenes. These metabolites were identified as (4S)-cadin-10(15)-en-3-one, (4S)-3 alpha-hydroxycadin-10(15)-ene, (4R)-3 alpha-hydloxycadin-10(15)-ene, (4S)-3 beta-hydroxycadin-10(15)-ene, (4S)-3 beta-hydroxycadina-10(15),12(14)-diene, (4S)-13-hydroxycadin-10(15)-en-3-one, (4S)-12-hydroxycadin-10(15)-en-3-one, (4R)-3 beta,14-dihydroxycadin-10(15)-ene and 3 alpha-hydroxycadina-4,10(15)diene. The allylic alcohol 3 alpha-hydroxycadina-4 10(15)-diene was also biotransformed to afford cadina-4,10(15)-dien-3-one, (4S)-cadin-10(15)-en-3-one and (4S)-12-hpdroxycadin-10(15)-en-3-one. The insecticidal potential and phytotoxicity of the isolated metabolites have been evaluated, (C) 2000 Elsevier Science Ltd. All rights reserved. [References: 14]