Synthesis, Characterization, and Antitumor Activity of Some Metal Complexes with Schiff Bases Derived from 9-Fluorenone as a Polycyclic Aromatic Compound

摘要

New bidendate Schiff base ligands HL~1 [(9H-fluorene-9-ylidene)thiosemicarbazide], HL~2 [(9H-fluorene-9-ylidene)semicarbazide] and L3~ [N~1,N~2di(9H-fluorene-9-ylidene)ethan-1,2-diamine] derived from the condensation of thiosemicarbazide, semicarbazide, and ethylenediamine with 9-fluorenone as polycyclic aromatic compound (PAC). Ag(I), Cu(II), VO(IV), La(III), and Zn(II) of the ligands HL~1, HL~2, and L~3 have been prepared and characterized by conductance and magnetic measurements, and electronic, infrared, and 1H NMR spectral data. Tetrahedral structures are suggested for Ag (I) with HL~1, HL~2, and L~3, whereas Cu(II)-HL~1 and VO(IV)-HL~2 have octahedral and square-planar structures, respectively. The Erlich antitumor activity in vivo (E. A. A.) have been studied and showed that the free ligands L~3, HL~2, and its VO(IV)-HL~2 complex are the most active in the inhibition of cell viability, whereas the ligands HL~1, La(III) -L~3, and Cu(II)-HL~1 are the least active ones.