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首页> 外文期刊>Physics in medicine and biology. >Rapid dual-injection single-scan 13N-ammonia PET for quantification of rest and stress myocardial blood flows.
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Rapid dual-injection single-scan 13N-ammonia PET for quantification of rest and stress myocardial blood flows.

机译:快速两次注射单次扫描13N氨PET定量定量静息和应激性心肌血流。

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摘要

Quantification of myocardial blood flows at rest and stress using 13N-ammonia PET is an established method; however, current techniques require a waiting period of about 1 h between scans. The objective of this study was to test a rapid dual-injection single-scan approach, where 13N-ammonia injections are administered 10 min apart during rest and adenosine stress. Dynamic PET data were acquired in six human subjects using imaging protocols that provided separate single-injection scans as gold standards. Rest and stress data were combined to emulate rapid dual-injection data so that the underlying activity from each injection was known exactly. Regional blood flow estimates were computed from the dual-injection data using two methods: background subtraction and combined modelling. The rapid dual-injection approach provided blood flow estimates very similar to the conventional single-injection standards. Rest blood flow estimates were affected very little by the dual-injection approach, and stress estimates correlated strongly with separate single-injection values (r=0.998, mean absolute difference=0.06 ml min-1 g-1). An actual rapid dual-injection scan was successfully acquired in one subject and further demonstrates feasibility of the method. This study with a limited dataset demonstrates that blood flow quantification can be obtained in only 20 min by the rapid dual-injection approach with accuracy similar to that of conventional separate rest and stress scans. The rapid dual-injection approach merits further development and additional evaluation for potential clinical use.
机译:建立使用13N氨PET定量分析静止和压力下心肌血流的方法;但是,当前的技术在两次扫描之间需要大约1小时的等待时间。这项研究的目的是测试一种快速的双注射单扫描方法,该方法在休息和腺苷应激期间相隔10分钟进行13N氨注射。使用提供单独的单次扫描扫描作为金标准的成像方案在六个人类受试者中获取动态PET数据。将休息和压力数据组合起来,以模拟快速两次注射数据,以便准确了解每次注射的潜在活动。使用两种方法从双重注入数据中计算区域血流量估计值:背景扣除和组合建模。快速双次注射方法提供的血流估计值与常规单次注射标准非常相似。两次注射方法对静息血流估计的影响很小,压力估计值与单独的一次注射值密切相关(r = 0.998,平均绝对差= 0.06 ml min-1 g-1)。在一个受试者中成功获得了一次实际的快速双次注射扫描,进一步证明了该方法的可行性。这项具有有限数据集的研究表明,通过快速双次注射方法只能在20分钟内获得血流定量,其准确性与传统的单独休息和压力扫描相似。快速的双重注射方法值得进一步开发和对潜在临床用途的额外评估。

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