SYNTHESIS AND PHARMACOLOGICAL ACTIVITYOF 10-ALKYLAMINOETHYL-2,3,4,10-TETRAHYDROPYRIMIDO-[l,2-alpha]BENZIMIDAZOLES

摘要

The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[l,2-alpha]benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result, 10-alkylaminoethyl-substituted derivatives of this tricycle containing alkylamines and 4-substituted piperazines were obtained. These compounds exhibited 5-HT_2 antagonist activity; platelet antiaggregant properties; and moderate P2Y,-antagonist, antiarrhythmic, and hypoglycemic action.