DRUG SYNTHESIS METHODS AND MANUFACTURING TECHNOLOGY INTERPOLYMER COMBINATIONS OF CHEMICALLY COMPLEMENTARY GRADES OF EUDRAGIT COPOLYMERS: A NEW DIRECTION IN THE DESIGN OF PERORAL SOLID DOSAGE FORMS OF DRUG DELIVERY SYSTEMS WITH CONTROLLED RELEASE (REVIEW)

摘要

Principles of the combination of chemically complementary grades of Eudragit~R copolymers in peroral, matrix, and reservoir types of solid dosage forms with modified release [tablets, microspheres, (micro)pellets] and their manufacturing technology (including film coatings) are considered. Modified drug release is achieved due to the interaction between reactive groups of copolymer pairs, which controls the drug release process both inside matrices and within multilayers or combined coatings. Analysis of these processes has key significance for developing (meth)acrylate polycomplexes, which could be synthesized in both aqueous and organic media, as new classes of drug carriers for constructing modem peroral drug delivery systems.