Maternal rubella infection occurring more than several weeks prior to conception presents no risk to the developing fetus. When maternal infection occurs in the first 12 weeks of pregnancy, especially during the first 8 weeks, more than 80% of fetuses develop significant congenital defects. During those 8 weeks, there is a 20% risk of spontaneous abortion. Major defects in children born with CRS include sensorineural hearing loss, heart disease, cataracts, and psychomotor retardation. Other organ systems also can be affected.
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