The authors' reply to the comments by Urban et al. on 'Skin transplantation to monitor clinical donor-related tolerance in mixed hematopoietic chimerism' (Pediatr Transplant 2006; 10: 128-131)

摘要

Our case report focused on a child with chronic renal failure, in whom the potential risks of a living-related kidney donation from her mother -her former hematopoietic cell donor - had to be assessed. The method of hematopoietic cell transplantation (HCT) applied in this patient had already been described by Schwinger et al. (1). As mentioned in the discussion section, the administration of a non-myeloablative conditioning regimen before HCT may favor the continued presence of recipient hematopoiesis. If this occurs, the development of mixed chimerism bears an increased risk of hematopoietic graft rejection and treatment with donor lymphocyte infusions (DLI) to establish complete donor hematopoiesis has been recommended (2).