Behcet disease is a complex, multisystem disease characterized by recurrent oral and genital ulcerations. It rarely occurs in infants or children. Neonatal Behcet disease has been reported in infants whose ulcers resolve at or before 9weeks of age. Few cases of neonatal Behcet disease persisting into childhood have previously been reported. We report the case of a 1-month-old infant who presented with severe recurrent genital ulcerations and at 6months developed recurrent oral ulcerations. Her orogenital ulcerations continue to recur. Human leukocyte antigen testing revealed HLA-B51 and B44 positivity. This is a case of pediatric Behcet disease in the neonatal period. Behcet disease should be considered in the differential diagnosis of recurrent genital and oral ulcerations in infants and children.
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