Pulmonary ventilation and micro-structural findings in congenital diaphragmatic hernia

摘要

BackgroundWith increasing survival of patients with more severe forms of congenital diaphragmatic hernia (CDH) and risk of long-term respiratory morbidity, studies on lung morphology are needed. We used hyperpolarised He-3 MRI and anatomical H-1 MRI in a cohort of young adult CDH patients to image regional lung ventilation and microstructure, focusing on morphological and micro-structural (alveolar) abnormalities.